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They enhance glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release from alpha cells, and act on the central nervous system to reduce appetite and food intake

For employers and health plans, the priority remains the same: ensuring the best possible care at the most sustainable cost

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Particular concerns exist for those with: Type 2 diabetes or pre-diabetes , due to opposing and unpredictable glycaemic effects Cardiovascular disease , given the potential for heart rate changes and fluid retention associated with GH Active malignancy , as GH stimulation is contraindicated in this setting Pregnancy or breastfeeding neither agent should be used during pregnancy or whilst breastfeeding

The gap between your current weight and your pre-pregnancy weight starts closing in a way that feels real rather than aspirational